Technical Disease Card

Feline leukaemia virus (FeLV)(Infection with)

Feline leukaemia virus (FeLV) is an exogenous gammaretrovirus (enveloped, single-stranded RNA) enzootic to domestic cats. The course of disease is somewhat variable pending the infectious strain of FeLV (FeLV-A, -B, or -C) and what endogenous retroviruses are present in the host’s genome. It is the recombination of these retroviruses within the host that influence pathogenicity. The surface glycoprotein and promoter region sequence of the infecting FeLV strain are the two most significant pathogenic determinants.