Technical Disease Card

Flavivirus (causing tick borne encephalitis) (Infection with)

Tickborne encephalitis virus (TBEV) is an arboviral flavivirus (enveloped, positive-sense, single-stranded RNA) enzootic to Eurasia and Japan. There are five known subtypes: European (TBEV-Eu), Siberian (TBEVSib), Far Eastern (TBEV-Fe), Himalayan (TBEV-Him), and Baikalian (TBEV-Bkl). Historically, it has been referred to as “Russian spring summer encephalitis” in Russia and “Central European encephalitis” in Europe.
TBEV is closely related to Louping ill virus (LIV), from which it is often clinically indistinguishable due to similarities in disease presentation. It is also a zoonotic agent and infects thousands of people annually.